Publications

2022

Membrane ruffling is a mechanosensor of extracellular fluid viscosity.
Matthew Pittman, Ernest Iu, Keva Li, Mingjiu Wang, Junjie Chen, Nilay Taneja, Myung Hyun Jo, Seungman Park, Wei-Hung Jung, Le Liang, Ishan Barman, Taekjip Ha, Stavros Gaitanaros, Jian Liu, Dylan Burnette, Sergey Plotnikov & Yun Chen.
Nature Physics. 2022 Jul 25;(18). https://doi.org/10.1038/s41567-022-01676-y

2021

Force-dependent activation of actin elongation factor mDia1 protects the cytoskeleton from mechanical damage and promotes stress fiber repair. Valencia FR, Sandoval E, Du J, Iu E, Liu J, Plotnikov SV.

Developmental Cell. 2021 Dec 6;56(23):3288-3302.e5. doi: 10.1016/j.devcel.2021.11.004.

Control of Cell Geometry through Infrared Laser Assisted Micropatterning.
Yang S, Tuo C, Iu E, Plotnikov SV.
J Vis Exp. 2021 Jul 10;(173). doi: 10.3791/62492.

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading.
Iu E, Bogatch A, Plotnikov SV.
J Vis Exp. 2021 May 22;(171). doi: 10.3791/62369.

Quantitative Analysis of Myofibroblast Contraction by Traction Force Microscopy.
Yang S, Valencia FR, Sabass B, Plotnikov SV.
Methods Mol Biol. 2021;2299:181-195. doi: 10.1007/978-1-0716-1382-5_14.

Cold stimulated cytoskeletal arrest in western painted turtle hepatocytes. 

Myrka AM, Frost R, Distefano D, Plotnikov SV, Buck LT.
Integrative and Comparative Biology. 2021 May 14;61, E642-E643. https://doi.org/10.1096/fasebj.2021.35.S1.01536

Mechanosensitive Regulation of Fibrosis.
Yang S, Plotnikov SV.

Cells. 2021 Apr 23;10(5):994. doi: 10.3390/cells10050994.

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2019

Synthesis, characterization, in vitro biocompatibility and antibacterial properties study of nanocomposite materials based on hydroxyapatite-biphasic ZnO micro- and nanoparticles embedded in Alginate matrix.
Turlybekuly A, Pogrebnjak AD, Sukhodub LF, Sukhodub LB, Kistaubayeva AS, Savitskaya IS, Shokatayeva DH, Bondar OV, Shaimardanov ZK, Plotnikov SV, Shaimardanova BH, Digel I.
Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109965. doi: 10.1016/j.msec.2019.109965.

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A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions.
Rafiq NBM, Nishimura Y, Plotnikov SV, Thiagarajan V, Zhang Z, Shi S, Natarajan M, Viasnoff V, Kanchanawong P, Jones GE, Bershadsky AD. 

Nat Mater. 2019 Jun;18(6):638-649. doi: 10.1038/s41563-019-0371-y.

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Coupling of Human Rhodopsin to a Yeast Signaling Pathway Enables Characterization of Mutations Associated with Retinal Disease.
Scott BM, Chen SK, Bhattacharyya N, Moalim AY, Plotnikov SV, Heon E, Peisajovich SG, Chang BSW.
Genetics. 2019 Feb;211(2):597-615. doi: 10.1534/genetics.118.301733.

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A noisy analog-to-digital converter connects cytosolic calcium bursts to transcription factor nuclear localization pulses in yeast
IS Hsu, B Strome, S Plotnikov, AM Moses
G3: Genes, Genomes, Genetics 9 Feb 7. (2), 561-570

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2018

Characterizing the role of actomyosin contractility in podocalyxin-driven collective tumor invasion.

EM Bell, ML Graves, PM Dean, K Goodwin, SV Plotnikov, KM McNagny, CD Roskelley.
Molecular Biology of the Cell. 2018 Dec;29 (26)

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Talin autoinhibition regulates cell-ECM adhesion dynamics and wound healing in vivo.
A Haage, K Goodwin, A Whitewood, D Camp, A Bogutz, CT Turner, DJ Granville, L Lefebvre, SV Plotnikov, BT Goult, G Tanentzapf.
Cell Reports. 2018 Nov 27;25 (9), 2401-2416. e5

2017

Two Distinct Actin Networks Mediate Traction Oscillations to Confer Focal Adhesion Mechanosensing.
Wu Z, Plotnikov SV, Moalim AY, Waterman CM, Liu J.
Biophys J. 2017 Feb 28;112(4):780-794. doi: 10.1016/j.bpj.2016.12.035.

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2016

Bridging the gap. Armitage SK, Plotnikov SV. Elife. 2016 Aug 23;5:e19733

A lateral signalling pathway coordinates shape volatility during cell migration. Zhang L, Luga V, Armitage SK, Musiol M, Won A, Yip CM, Plotnikov SV, Wrana JL. Nat Commun. 2016 May 26;7:11714.

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2015

Inverted formin 2 in focal adhesions promotes dorsal stress fiber and fibrillar adhesion formation to drive extracellular matrix assembly. Skau CT, Plotnikov SV, Doyle AD, Waterman CM. Proc. Natl. Acad. Sci. U.S.A. 2015 Apr;
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Rac1-dependent phosphorylation and focal adhesion recruitment of myosin IIA regulates migration and mechanosensing. Pasapera AM, Plotnikov SV, Fischer RS, Case LB, Egelhoff TT, Waterman CM. Curr. Biol. 2015 Jan;25(2):175-86
pubmed

2014

High-resolution traction force microscopy. Plotnikov SV, Sabass B, Schwarz US, Waterman CM. Methods Cell Biol. 2014;123:367-94
pubmed

2013

Vinculin-actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth. Thievessen I, Thompson PM, Berlemont S, Plevock KM, Plotnikov SV, Zemljic-Harpf A, Ross RS, Davidson MW, Danuser G, Campbell SL, Waterman CM. J. Cell Biol. 2013 Jul;202(1):163-77
pubmed

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Guiding cell migration by tugging. Plotnikov SV, Waterman CM. Curr. Opin. Cell Biol. 2013 Oct;25(5):619-26
pubmed

2012

Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration. Plotnikov SV, Pasapera AM, Sabass B, Waterman CM. Cell 2012 Dec;151(7):1513-27. doi: 10.1016/j.cell.2012.11.034

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Second harmonic generation microscopy for quantitative analysis of collagen fibrillar structure. Chen X, Nadiarynkh O, Plotnikov S, Campagnola PJ. Nat Protoc 2012 Apr;7(4):654-69

2009

Cardiac fibroblasts require focal adhesion kinase for normal proliferation and migration. Manso AM, Kang SM, Plotnikov SV, Thievessen I, Oh J, Beggs HE, Ross RS. Am. J. Physiol. Heart Circ. Physiol. 2009 Mar;296(3):H627-38

2008

Measurement of muscle disease by quantitative second-harmonic generation imaging. Plotnikov SV, Kenny AM, Walsh SJ, Zubrowski B, Joseph C, Scranton VL, Kuchel GA, Dauser D, Xu M, Pilbeam CC, Adams DJ, Dougherty RP, Campagnola PJ, Mohler WA. J Biomed Opt 2008 Jul-Aug;13(4):044018

2007

Second harmonic generation imaging microscopy studies of osteogenesis imperfecta. Nadiarnykh O, Plotnikov S, Mohler WA, Kalajzic I, Redford-Badwal D, Campagnola PJ. J Biomed Opt 2007 Sep-Oct;12(5):051805
pubmed

2006

Characterization of the myosin-based source for second-harmonic generation from muscle sarcomeres. Plotnikov SV, Millard AC, Campagnola PJ, Mohler WA. Biophys. J. 2006 Jan;90(2):693-703
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Optical clearing for improved contrast in second harmonic generation imaging of skeletal muscle. Plotnikov S, Juneja V, Isaacson AB, Mohler WA, Campagnola PJ. Biophys. J. 2006 Jan;90(1):328-39